Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Antagonism by Aspirin and Fenamates of Bronchoconstriction and Nociception induced by Adenosine-5′-triphosphate

Abstract

ADENOSINE triphosphate (ATP) and related adenosine phosphates cause bronchoconstriction in guinea-pig isolated lungs, and, in relatively high doses, increase air overflow volume in the Konzett-Rössler preparation of guinea-pig lungs in vivo1. ATP elicits pain in man when applied to an exposed blister base2, as do several other endogenous substances that induce bronchoconstriction in the guinea-pig. We have confirmed that ATP increases air overflow volume in the Konzett-Rössler preparation of the guinea-pig and we have found that, in keeping with its algogenic action in man, ATP induced a nociceptive response in mice. Both the bronchoconstrictor and the nociceptive responses were antagonized by salts of aspirin and of three aryl anthranilic acids (flufenamic3, mefenamic4 and meclofenamic5), which we shall collectively call ‘fenamates’.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Bianchi, A., De Natale, G., and Giaquinto, S., Arch. Intern. Pharmacodyn., 145, 498 (1963).

    CAS  Google Scholar 

  2. Keele, C. A., and Armstrong, D., Substances Producing Pain and Itch, 261 (Arnold, London, 1964).

    Google Scholar 

  3. Winder, C. V., Wax, J., Serrano, B., Jones, E. M., and McPhee, M. L., Arthritis and Rheumatism, 6, 36 (1963).

    Google Scholar 

  4. Winder, C. V., Wax, J., Scotti, L., Scherrer, R. A., Jones, E. M., and Short, F. W., J. Pharmacol. Exp. Therap., 138, 405 (1962).

    CAS  Google Scholar 

  5. Winder, C. V., Wax, J., and Welford, M., J. Pharmacol. Exp. Therap., 148, 422 (1965).

    CAS  Google Scholar 

  6. Konzett, H., and Rössler, R., Naunyn-Schmiedebergs Arch. Exp. Path. Pharmak., 195, 71 (1940).

    Article  Google Scholar 

  7. Collier, H. O. J., and Shorley, P. G., Brit. J. Pharmacol. Chemother., 15, 601 (1960).

    Article  CAS  Google Scholar 

  8. Collier, H. O. J., James, G. W. L., and Piper, P. J., J. Physiol., 180, 13P (1965).

    CAS  Google Scholar 

  9. Siegmund, E., Cadmus, R., and Lu, G., Proc. Soc. Exp. Biol. N.Y., 95, 729 (1957).

    Article  CAS  Google Scholar 

  10. Collier, H. O. J., Hammond, A. R., Horwood-Barrett, S., and Schneider, C., Nature, 204, 1316 (1964).

    Article  ADS  CAS  Google Scholar 

  11. Berry, P. A., and Collier, H. O. J., Brit. J. Pharmacol. Chemother., 23, 201 (1964).

    Article  CAS  Google Scholar 

  12. Aarsen, P. N., Brit. J. Pharmacol. Chemother., 27, 196 (1966).

    CAS  Google Scholar 

  13. Shibusawa, K., Tokuzawa, K., Kishi, S., Kajiya, Y., Kasuga, H., and Fujiwara, S., Gunma J. Med. Sci., Japan, 7, 91 and 101 (1958).

    Google Scholar 

  14. Back, N., Wilkens, H., and Steger, R., Hyposensitive Peptides, 485 (Springer, New York, 1966).

    Book  Google Scholar 

  15. Kitamura, M., Jap. J. Pharmacol., 15, 135 (1965).

    Article  CAS  Google Scholar 

  16. Collier, H. O. J., Hammond, A. R., and Whiteley, B., Nature, 200, 176 (1963).

    Article  ADS  CAS  Google Scholar 

  17. Collier, H. O. J., and James, G. W. L., J. Physiol., 185, 71P (1966).

    CAS  Google Scholar 

  18. Smith, M. J. H., Salicylates, 47 (Churchill, London, 1963).

    Google Scholar 

  19. Whitehouse, M. W., Non-steroidal Anti-inflammatory Drugs, 52 (Excerpta Medica, Amsterdam, 1965).

    Google Scholar 

  20. Collier, H. O. J., and Shorley, P. G., Brit. J. Pharmacol. Chemother., 20, 345 (1963).

    Article  CAS  Google Scholar 

  21. Bhoola, K. D., Collier, H. O. J., Schachter, M., and Shorley, P. G., Brit. J. Pharmacol. Chemother., 19, 190 (1962).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

COLLIER, H., JAMES, G. & SCHNEIDER, C. Antagonism by Aspirin and Fenamates of Bronchoconstriction and Nociception induced by Adenosine-5′-triphosphate. Nature 212, 411–412 (1966). https://doi.org/10.1038/212411a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/212411a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing