Abstract
5-Hydroxytryptamine (5-HT), seems to be involved in depression and perhaps schizophrenia. A behavioural test of 5-HT action in animals has been used to clarify the mechanism of its action and the effects of various drugs used clinically in affective disorders.
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References
Amin, A. H., Crawford, T. B. B., and Gaddum, J. H., J. Physiol., Lond., 126, 596–618 (1954).
Dahlström, A., Häggendal, J., and Atack, C., in Serotonin and Behaviour, 87–96 (Academic, New York, 1973).
Aghajanian, G. K., and Bloom, F. E., J. Pharmac. exp. Ther., 156, 23–30 (1967).
Green, A. R., and Grahame-Smith, D. G., in Handbook of Psychopharmacology, 3, 169–245 (Plenum, New York, 1975).
Myers, R. D., in Serotonin and Behaviour, 293–302 (Academic, New York, 1973).
Jouvet, M., in Serotonin and Behaviour, 385–400 (Academic, New York, 1973).
Sicuteri, F., Anselmi, B., and Del Bianco, P. L., Psychopharmacologia, 29, 347–356 (1973).
Grahame-Smith, D. G., Biochem. Soc. Publ., 1, 197–207 (1974).
Gal, E. M., Drewes, P. A., and Barraclough, L. A., Proc. first Int. Pharmac. Meeting, 8, 107–118 (1962).
Wang, H. L., Harwalker, V. H., and Waisman, H. A., Archs Biochem. Biophys., 96, 181–184 (1962).
Ashcroft, G. W., Eccleston, D., and Crawford, T. B. B., J. Neurochem., 12, 483–503 (1965).
Fernstrom, J. D., and Wurtman, R. J., Science, 173, 149–152 (1971).
Curzon, G., Joseph, M. H., and Knott, P. J., J. Neurochem., 19, 1967–1974 (1972).
Perez-Cruet, J., Tagliamonte, A., Tagliamonte, P., and Gessa, G. L., Life Sci. 11, 31–39 (1972).
Knott, P. J., Joseph, M. H., and Curzon, G., J. Neurochem., 20, 249–251 (1973).
Knott, P. J., and Curzon, G., Nature, 239, 452–453 (1972).
McMenamy, R. H., and Onckley, J. L., J. biol. Chem., 233, 1436–1447 (1958).
Tagliamonte, A., Tagliamonte, P., Perez-Cruet, J., and Gessa, G. L., Nature new Biol., 229, 125–126 (1971).
Tagliamonte, A., Tagliamonte, P., Perez-Cruet, J., Stern, S., and Gessa, G. L., J. Pharmac. exp. Ther., 177, 475–480 (1971).
Tagliamonte, A., Biggio, G., Vargiu, L., and Gessa, G. L., J. Neurochem., 20, 909–912 (1973).
Curzon, G., Friedel, J., and Knott, P. J., Nature new Biol., 242, 198–200 (1973).
Curzon, G., and Knott, P. J., Br. J. Pharmac., 50, 197–204 (1974).
Madras, B. K., Cohen, E. C., Messing, R., Munro, H. M., and Wurtman, R. J., Metabolism, 23, 1107–1116 (1974).
Fernstrom, J. D., and Wurtman, R. J., Metabolism, 21, 337–342 (1972).
Fernstrom, J. D., and Wurtman, R. J., Science, 174, 1023–1025 (1971).
Fernstrom, J. D., and Wurtman, R. J., Science, 178, 414–416 (1972).
Green, A. R., Sourkes, T. L., and Young, S. N., Br. J. Pharmac., 53, 287–292 (1975).
Green, A. R., and Curzon, G., Nature, 220, 1095–1097 (1968).
Green, A. R., Woods, H. F., Knott, P. J., and Curzon, G., Nature, 255, 170 (1975).
Hery, F., Rouer, E., and Glowinski, J., Brain Res., 43, 445–465 (1972).
Grahame-Smith, D. G., and Parfitt, A., J. Neurochem.,, 17, 1339–1353 (1970).
Parfitt, A., and Grahame-Smith, D. G., Ciba Fndn Symp., 22, 175–192 (1973).
Hamon, M., Bourgion, S., and Glowinski, J., J. Neurochem., 20, 1727–1745 (1973).
Macon, J. B., Sokoloff, L., and Glowinski, J., J. Neurochem., 18, 323–331 (1971).
Hamon, M., and Glowinski, J., Life Sci., 15, 1533–1548 (1974).
Carlsson, A., Bedard, P., Lindqvist, M., and Magnusson, T., in Neurotransmitters and Metabolic Regulation (Biochem. Soc. London, 1972).
Millard, S. A., Costa, E., and Gal, E. M., Brain Res. 40, 545–551 (1972).
Carlsson, A., Corrodi, H., Fuxe, K., and Hökfelt, T., Eur. J. Pharmac., 5, 367–373 (1969).
Carlsson, A., Corrodi, H., Fuxe, K., and Hökfelt, T., Eur. J. Pharmac., 5, 357–366 (1969).
Meek, J., and Werdinius, B., J. Pharm. Pharmac., 22, 141–143 (1970).
Green, A. R., and Grahame-Smith, D. G., Neuropharmacology, 14, 107–113 (1975).
Meek, J. L., Fuxe, K., and Andén, N-E., Eur. J. Pharmac., 9, 325–332 (1970).
Modigh, K., J. Neural Transmission, 34, 101–109 (1973).
Modigh, K., J. Pharm. Pharmac., 25, 926–928 (1973).
Sheard, M. H., and Aghajanian, G. K., J. Pharmac. exp. Ther., 163, 425–430 (1968).
Kuhar, M. J., Roth, R. H., and Aghajanian, G. K., Brain Res., 35, 167–176 (1971).
Sheard, M. H., Zolovich, A., and Aghajanian, G. K., Brain Res., 43, 690–694 (1972).
Bruinvels, J., Eur. J. Pharmac., 20, 231–237 (1972).
Grahame-Smith, D. G., J. Neurochem., 18, 1053–1066 (1971).
Jacobs, B. L., Eubanks, E. E., and Wise, W. D., Neuropharmacology, 13, 575–583 (1974).
Jacobs, B. L., Mosko, S. S., and Trulson, M. E., in Neurobiology of Sleep and Memory (edit. by Drucker-Colin, R. R., and McGaugh, J. L.) (Academic, New York, in the press).
Jacobs, B. L., and Klemfuss, H., Brain Res., 100, 450–457 (1975).
Green, A. R., and Youdim, M. B. H., Br. J. Pharmac., 55, 415–422 (1975).
Foldes, A., and Costa, E., Biochem. Pharmac., 24, 1617–1621 (1975).
Grahame-Smith, D. G., Adv. Biochem. Psychopharm., 10, 83–91 (1973).
Garelis, E., Young, S. N., Lal, S., and Sourkes, T. L., Brain Res., 79, 1–8 (1974).
Grahame-Smith, D. G., Br. J. Pharmac., 43, 856–864 (1971).
Grahame-Smith, D. G., and Green, A. R., Br. J. Pharmac., 52, 19–26 (1974).
Collard, M. J., and Roberts, M. H. T., Br. J. Pharmac., 55, 268P (1975).
Chadwick, D., Jenner, P., and Reynolds, E. H., Lancet, i, 473–476 (1975).
Green, A. R., and Grahame-Smith, D. G., Lancet, i, 639–640 (1975).
Mendels, J., Lancet, i, 342 (1971).
Wilk, S., Shopsin, B., Gershon, S., and Suhd, M., Nature, 235, 440–441 (1972).
Iversen, L. L., Br. med. Bull., 29, 130–135 (1973).
Snyder, S. H., Shaskan, E. G., and Kuhar, M. J., in Serotonin and Behaviour, 97–108 (Academic, New York, 1973).
Green, A. R., Tordoff, A. F. C., and Bloomfield, M. R., J. Neural Transmission (in the press).
Green, A. R., and Grahame-Smith, D. G., Neuropharmacology, 13, 949–959 (1974).
Green, A. R., Youdim, M. B. H., and Grahame-Smith, D. G., Neuropharmacology 15 173–179 (1976).
Andén, N-E., Adv. Pharmac., 6 A, 347–349 (1968).
Gordon, M., in Psychopharmacological Agents, 2, 1–198 (Academic, New York, 1967).
Evans, J. P. M., Grahame-Smith, D. G., Green, A. R., and Tordoff, A. F. C., Br. J. Pharmac., 56 193–199 (1976).
Shields, P. J., J. Pharm. Pharmac., 24, 919–920 (1972).
Tagliamonte, A., Tagliamonte, P., Dichiara, G., Gessa, R., and Gessa, G. L., J. Neurochem., 19, 1509–1512 (1972).
Modigh, K., J. Neural Transmission, 36, 19–32 (1975).
Green, A. R., and Grahame-Smith, D. G., Nature, 251, 524–526 (1974).
Prange, A. J., Breese, G. R., Wilson, I. C., and Lipton, M. A., in Anatomical Neuroendocrinology (Karger, Basel, in the press).
Plotnikoif, N. P., Prange, A. J., Breese, G. R., Anderson, M. S., and Wilson, I. C., Science, 178, 417–418 (1972).
Green, A. R., and Kelly, P. H., Br. J. Pharmac. (in the press).
Breese, G. R., Cott, J. M., Cooper, B. R., Prange, A. J., Lipton, M. A., and Plotnikoff, N. P., J. Pharmac. exp. Ther., 193, 11–22 (1975).
Grahame-Smith, D. G., J. Neurochem., 19, 2409–2422 (1972).
Green, A. R., Heal, D. J., Grahame-Smith, D. G., and Kelly, P. H., Neuropharmacology (in the press).
Cohn, M. L., Cohn, M., and Taylor, F. H., Brain Res., 96, 134–137 (1975).
Davis, K. E., Hollister, L. E., and Berger, P. A., Am. J. Psychiat., 132, 951–953 (1975).
Bigelow, L. B., Gillin, J. C., Semal, C., and Wyatt, R. J., Lancet, ii, 869–870 (1975).
Winokur, A., and Utiger, R. D., Science, 185, 265–266 (1974).
Brownstein, M. J., Palkovits, M., Saavedra, J. M., Bassiri, R. M., and Utiger, R. D., Science, 185, 267–269 (1974).
Griffiths, E. C., Hooper, K. C., and Jeffcoate, S. L., Lancet, ii, 554 (1975).
Coppen, A. J., Shaw, D. M., and Farrell, J. P., Lancet, i, 79–81 (1963).
Grahame-Smith, D. G., in Serotonin and Behaviour, 563–564 (Academic, New York, 1973).
Andén, N-E., Corrodi, H., and Fuxe, K., J. Pharmac. exp. Ther., 179, 236–249 (1971).
Greenberg, R., in Chemical Modulation of Brain Function, 277–296 (Raven, New York, 1973).
Himwich, H. E., et al., in Chemical Modulation of Brain Function, 297–312 (Raven, New York, 1973).
Pollin, W., Cardon, P. V., and Kety, S., Science, 133, 104–105 (1961).
Barbeau, A., Can. Med. Ass. J., 87, 802–807 (1962).
Eccleston, D., et al., J. Neurochem., 15, 947–957 (1968).
Moir, A. T. B., Ashcroft, G. W., Crawford, T. B. B., Eccleston, D., and Guldberg, H. C., Brain, 93, 357–368 (1970).
Ashcroft, G. W., et al., Psychol. Med., 3, 326–332 (1973).
Chase, T. N., Archs Neurol., 27, 354–356 (1972).
Bulat, M., and Zivkoviĉ, B., Science, 173, 738–740 (1971).
Weir, R. L., Chase, T. N., Ng, L. K. Y., and Kopin, I. J., Brain Res., 52, 409–412 (1973).
Garelis, E., and Sourkes, T. L., J. Neurol. Neurosurg. Psychiat., 36, 625–629 (1973).
Young, S. N., Lal, S., Martin, J. B., Ford, R. M., and Sourkes, T. L., Psychiat. Neurol. Neurochir., 76, 439–444 (1973).
Curzon, G., Gumpert, E. J. W., and Sharpe, D. M., Nature new Biol., 231, 189–191 (1971).
Van Praag, H. M., and Korf, J., in Serotonin and Behaviour, 457–468 (Academic. New York, 1973).
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Richard Green, A., Grahame-Smith, D. Effects of drugs on the processes regulating the functional activity of brain 5-hydroxytryptamine. Nature 260, 487–491 (1976). https://doi.org/10.1038/260487a0
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DOI: https://doi.org/10.1038/260487a0
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