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The role of hormone receptors and GTP-regulatory proteins in membrane transduction

Nature volume 284, pages 17–22 (1980)Cite this article

Abstract

Cell membrane receptors for hormones and neurotransmitters form oligomeric complexes with GTP-regulatory proteins and inhibit the latter from reacting with GTP. Hormones and neurotransmitters act by releasing the inhibitory constraints imposed by the receptors, thus allowing the GTP-regulatory proteins to interact with and control the activity of enzymes such as adenylate cyclase. This theory may apply generally to membrane signal transduction involving surface receptors.

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  1. Laboratory of Nutrition and Endocrinology, National Institute of Arthritis, Metabolic and Digestive Diseases, National Institutes of Health, Bethesda, Maryland, 20205

    Martin Rodbell

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Rodbell, M. The role of hormone receptors and GTP-regulatory proteins in membrane transduction. Nature 284, 17–22 (1980). https://doi.org/10.1038/284017a0

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