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Single channel recordings of K+ currents in squid axons

Abstract

Ionic currents from individual K+ channels in squid axon membrane have been recorded. At hyperpolarizing membrane voltages, unit events occur as widely spaced rectangular pulses with short interruptions. The frequency of occurrence of the units increases strongly when the membrane is depolarized.

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References

  1. Hodgkin, A. L. & Huxley, A. F. J. Physiol., Lond. 117, 500–544 (1952).

    Article  CAS  Google Scholar 

  2. Hille, B. in Membranes: Lipid Bilayers and Biological Membranes: Dynamic Properties Vol. 3 (ed. Eisenman, G., 255–323 (Dekker, New York, 1975).

    Google Scholar 

  3. Ritchie, J. M. & Rogart, R. B. Rev. Physiol. biochem. Pharmac. 79, 1–50 (1977).

    Article  CAS  Google Scholar 

  4. Conti, F., De Felice, L. J. & Wanke, E. J. Physiol., Lond. 248, 45–82 (1975).

    Article  CAS  Google Scholar 

  5. Begenisich, T. & Stevens, C. F. Biophys. J. 15, 843–846 (1975).

    Article  ADS  CAS  Google Scholar 

  6. Conti, F., Hille, B., Neumcke, B., Nonner, W. & Staempfli, R. J. Physiol., Lond. 262, 699–727 (1976).

    Article  CAS  Google Scholar 

  7. Sigworth, F. J. Nature 270, 265–267 (1977).

    Article  ADS  CAS  Google Scholar 

  8. Neher, E., Sakmann, B. & Steinbach, J. H. Pflügers Arch. ges. Physiol. 375, 219–228 (1978).

    Article  CAS  Google Scholar 

  9. Tasaki, I., Watanabe, A. & Takenaka, T. Proc. natn. Acad. Sci. U.S.A. 48, 117–1184 (1962).

    Google Scholar 

  10. Armstrong, C. M., Bezanilla, F. & Rojas, E. J. gen. Physiol. 62, 375–391 (1973).

    Article  CAS  Google Scholar 

  11. Chandler, W. K., Hodgkin, A. L. & Meves, H. J. Physiol., Lond. 180, 821–836 (1965).

    Article  CAS  Google Scholar 

  12. Ehrenstein, G. & Gilbert, D. L. Biophys. J. 6, 553–566 (1966).

    Article  CAS  Google Scholar 

  13. Neher, E. & Steinbach, J. H. J. Physiol., Lond. 227, 153–176 (1978).

    Article  Google Scholar 

  14. Bezanilla, F. & Armstrong, C. M. J. gen. Physiol. 60, 558–608 (1972).

    Article  Google Scholar 

  15. Keynes, R. D. & Lewis, P. R. J. Physiol., Lond. 114, 151–182 (1951).

    Article  CAS  Google Scholar 

  16. Stuehmer, W. & Conti, F., in preparation

  17. Colquhoun, D. & Hawkes, A. G. Proc. R. Soc. B199, 231–262 (1977).

    ADS  CAS  Google Scholar 

  18. Armstrong, C. M. J. gen. Physiol. 58, 413–437 (1971).

    Article  CAS  Google Scholar 

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Conti, F., Neher, E. Single channel recordings of K+ currents in squid axons. Nature 285, 140–143 (1980). https://doi.org/10.1038/285140a0

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