Abstract
A complementary DNA encoding an ATP-regulated potassium channel has been isolated by expression cloning from rat kidney. The predicted 45K protein, which features two potential membrane-spanning helices and a proposed ATP-binding domain, represents a major departure from the basic structural design characteristic of voltage-gated and second messenger-gated ion channels. But the presence of an H5 region, which is likely to form the ion conduction pathway, indicates that the protein may share a common origin with voltage-gated potassium channel proteins.
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Ho, K., Nichols, C., Lederer, W. et al. Cloning and expression of an inwardly rectifying ATP-regulated potassium channel. Nature 362, 31–38 (1993). https://doi.org/10.1038/362031a0
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DOI: https://doi.org/10.1038/362031a0
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