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Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

Abstract

The proteins Grb2–Sem-5, Shc and Sos have been implicated in the signalling pathway from tyrosine kinase receptors to Ras. Grb2–Sem-5 binds directly to murine Sos1, a Ras exchange factor, through two SH3 domains. Sos is also associated with ligand-activated tyrosine kinase receptors which bind Grb2–Sem-5, and with the Grb2–Sem-5 binding protein, Shc. Ectopic expression of Drosophila Sos stimulates morphological transformation of rodent fibroblasts. These data define a pathway by which tyrosine kinases act through Ras to control cell growth and differentiation.

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Egan, S., Giddings, B., Brooks, M. et al. Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature 363, 45–51 (1993). https://doi.org/10.1038/363045a0

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