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Inactivation properties of voltage-gated K+ channels altered by presence of β-subunit

Abstract

Structural and functional diversity of voltage-gated Kv1-type potassium channels in rat brain is enhanced by the association of two different types of subunits, the membrane-bound, pore-forming α-subunits and a peripheral β-subunit. We have cloned a β-subunit (Kvβ1) that is specifically expressed in the rat nervous system. Association of Kvβ1 with α-subunits confers rapid A-type inactivation on non-inactivating Kv1 channels (delayed rectifiers) in expression systems in vitro. This effect is mediated by an inactivating ball domain in the Kvβ1 amino terminus.

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Rettig, J., Heinemann, S., Wunder, F. et al. Inactivation properties of voltage-gated K+ channels altered by presence of β-subunit. Nature 369, 289–294 (1994). https://doi.org/10.1038/369289a0

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