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Therapeutic angiogenesis for heart failure

Abstract

A new study answers one set of questions, but raises many more, about the potential use of specific VEGF isoforms to promote re-vascularization for ischemic cardiomyopathy (pages 495-502).

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Figure 1: Observations by Carmeliet et al. in mice with restricted VEGF-A isoforms expression suggest new application for therapeutic angiogenesis:

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Isner, J., Losordo, D. Therapeutic angiogenesis for heart failure. Nat Med 5, 491–492 (1999). https://doi.org/10.1038/8374

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