Basic ResearchContribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat
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KEYWORDS
antibiotics
Cockcroft–Gault
creatinine
creatinine clearance
glomerular filtration rate
proximal tubule
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E-IL, JH, RB, BPM, GB, TC, and ASR are employed by and are shareholders of Gilead Sciences, which is marketing cobicistat as part of the combination pill STRIBILD for the treatment of HIV. XZ, JH, AK, and YH are employed by Optivia Biotechnology a contract service provider of transporter-related assays including the proprietary Opti-Expression transfection technology used in these studies.
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
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These authors contributed equally to this work.
Copyright © 2014 International Society of Nephrology. Published by Elsevier Inc.