Abstract
A paradoxical aspect of the transition to drug addiction is that drug users spend progressively more time and effort to obtain drug hedonic effects that continually decrease with repeated experience1,2. According to the hedonic allostasis hypothesis3, increased craving for and tolerance to the hedonic effects of drugs result from the same chronic alteration in the regulation of brain reward function (allostasis). Here we show in rats that repeated withdrawals from prolonged cocaine self-administration produces a persistent decrease in brain reward function that is highly correlated with escalation of cocaine intake and that reduces the hedonic impact of cocaine.
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Notes
NOTE: A mistake was introduced during the preparation of this paper. In the AOP version, panel labels b and c in Fig. 1 were mistakenly switched. The lower left panel should be labeled b, and the upper right panel should be labeled c. This mistake has been corrected in the HTML version and will appear correctly in print. The PDF version available online has been appended.
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Acknowledgements
Supported by the Centre National de la Recherche Scientifique (S.H.A.), the Peter McManus Charitable Trust (P.J.K.) and grants from the National Institute on Drug Abuse (DA04398 to G.F.K. and DA11946 to A.M.). This is manuscript number 14258-NP from The Scripps Research Institute.
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Ahmed, S., Kenny, P., Koob, G. et al. Neurobiological evidence for hedonic allostasis associated with escalating cocaine use. Nat Neurosci 5, 625–626 (2002). https://doi.org/10.1038/nn872
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DOI: https://doi.org/10.1038/nn872
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