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The emergence of the drug receptor theory

Abstract

Today, the concept of specific receptors for drugs and transmitters lies at the very heart of pharmacology. Less than one hundred years ago, this novel idea met with considerable resistance in the scientific community. To mark the 150th anniversary of the birth of John Newport Langley, one of the founders of the receptor concept, we highlight his most important observations, and those of Paul Ehrlich and Alfred Joseph Clark, who similarly helped to establish the receptor theory of drug action.

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Figure 3: The amboceptor.

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Acknowledgements

We gratefully acknowledge support from the Wellcome Trust (History of Medicine Project Grant).

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Correspondence to Robert F. Halliwell.

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DATABASES

Medscape DrugInfo

acetylcholine

atropine

morphine

nicotine

physostigmine

pilocarpine

quinine

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Maehle, AH., Prüll, CR. & Halliwell, R. The emergence of the drug receptor theory. Nat Rev Drug Discov 1, 637–641 (2002). https://doi.org/10.1038/nrd875

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