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A family-based and case–control association study of trace amine receptor genes on chromosome 6q23 in bipolar affective disorder

Molecular Psychiatry volume 10, pages 618–620 (2005)Cite this article

SIR — Trace amines are of interest in the study of neuropsychiatric disorders as they are found predominantly in the CNS, and altered levels have been observed in disorders such as schizophrenia, bipolar affective disorder, and anxiety disorders.1 The genes of the three trace amine receptors (TRARs) 1, 4, and 5 cluster on chromosomal region 6q23.2, a region for which we and others have previously obtained evidence for linkage to bipolar affective disorder.2, 3, 4 TRARs also share a high degree of sequence homology, and together form a subfamily of G protein-coupled receptors (GPCRs) that are related to serotonin- (5–HT-), dopamine- (DA-), and norepinephrine- (NE-) receptors.1

To explore genetic variability at this locus, we established a PCR-based strategy to amplify the coding regions, and the 5′ and 3′ flanking regions of the TRARs, namely TRAR1, TRAR4, and TRAR5. We used this to sequence DNA from a representative sample of 96 individuals from the European population.5 A total of 4467 bp of genomic DNA was screened, 3087 bp of which were exonic. Direct sequencing was performed as described elsewhere.5 We identified 12 SNPs in the three TRARs which were submitted to dbSNP (http://www.ncbi.nlm.nih.gov/) under accession nos. ss125870000–ss12587012 (see Supplementary information).

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Authors and Affiliations

  1. Institute of Human Genetics, University of Bonn, Bonn, Germany

    R Abou Jamra, I Sircar, Y Freudenberg-Hua, J Freudenberg, F Brockschmidt, P Propping & J Schumacher

  2. Institute of Medical Biometry, Informatics, and Epidemiology, University of Bonn, Bonn, Germany

    T Becker

  3. Central Institute of Mental Health, Mannheim, Germany

    S Ohlraun, T G Schulze, M Deschner, C Schmäl & M Rietschel

  4. Department of Psychiatry, University of Bonn, Bonn, Germany

    M Gross & W Maier

  5. Mental State Hospital, Psychiatrisches Zentrum Nordbaden, Wiesloch, Germany

    F Spira

  6. Life & Brain Center, University of Bonn, Bonn, Germany

    S Cichon & M M Nöthen

Authors
  1. R Abou Jamra
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  2. I Sircar
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  3. T Becker
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  4. Y Freudenberg-Hua
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  5. S Ohlraun
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  6. J Freudenberg
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  7. F Brockschmidt
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  8. T G Schulze
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  9. M Gross
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  10. F Spira
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  11. M Deschner
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  12. C Schmäl
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  13. W Maier
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  14. P Propping
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  15. M Rietschel
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  16. S Cichon
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  17. M M Nöthen
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  18. J Schumacher
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Correspondence to R Abou Jamra.

Additional information

Supplementary Information accompanies the paper Molecular Psychiatry website (http://www.nature.com/mp).

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Abou Jamra, R., Sircar, I., Becker, T. et al. A family-based and case–control association study of trace amine receptor genes on chromosome 6q23 in bipolar affective disorder. Mol Psychiatry 10, 618–620 (2005). https://doi.org/10.1038/sj.mp.4001665

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