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The MRP family of drug efflux pumps

Abstract

The MRP family is comprised of nine related ABC transporters that are able to transport structurally diverse lipophilic anions and function as drug efflux pumps. Investigations of this family have provided insights not only into cellular resistance mechanisms associated with natural product chemotherapeutic agents, antifolates and nucleotide analogs, but also into factors that influence drug distribution in the body, membrane systems that are involved in the extrusion of reduced folates, cysteinyl leukotrienes and bile acids, and the molecular basis of two hereditary conditions in humans. The review will describe the biochemical properties, drug resistance activities and potential in vivo functions of these unusual pumps.

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Acknowledgements

This work was supported in part by National Institutes of health Grants CA73728 (to GDK) and CA06927 to the Fox Chase Cancer Center and by an appropriation from the Commonwealth of Pennsylvania.

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Correspondence to Gary D Kruh.

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Kruh, G., Belinsky, M. The MRP family of drug efflux pumps. Oncogene 22, 7537–7552 (2003). https://doi.org/10.1038/sj.onc.1206953

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