Neutrophil elastase inhibitor reduces neutrophil chemoattractant production after ischemia-reperfusion in rat liver
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Glycyrrhetinic acid pretreatment attenuates liver ischemia/reperfusion injury via inhibiting TLR4 signaling cascade in mice
2019, International ImmunopharmacologyCitation Excerpt :Sterile inflammation (occurs in the absence of microorganisms), such as ischemia-reperfusion injury, trauma and chemically induced injury, is marked by abundant recruitment of neutrophils [4,30,31]. Inhibiting infiltration of neutrophils or activity of neutrophil elastase attenuated ischemia-reperfusion injury in rat liver [32,33]. In the current study, we evaluated the number of neutrophils infiltration in liver parenchyma by immunofluorescence and flow cytometry, and found that GA pretreatment significantly decreased neutrophils infiltration, which was consistent with the previous studies on anti-inflammation effect of GA.
Prevention of Leukocyte Activation by the Neutrophil Elastase Inhibitor, Sivelestat, in the Hepatic Microcirculation After Ischemia-Reperfusion
2009, Journal of Surgical ResearchCitation Excerpt :In this study, we did not investigate the cytokines. Previous reports have documented that sivelestat attenuated TNF-α and CINC production after hepatic I/R [11, 12]. Thus, it is possibility that sivelestat would suppress the inflammatory cytokines and activated macrophage, i.e., TNF-α, IL1, IL6, and Kupffer cell, stimulated by I/R.
Pyrrolidine dithiocarbamate prevents 60 minutes of warm mesenteric ischemia/reperfusion injury in rats
2007, American Journal of Surgery