Original ResearchBrief ReportIdentification of Candidate Oncogenes in Human Colorectal Cancers With Microsatellite Instability
Section snippets
Acknowledgments
The authors thank Sini Nieminen, Sirpa Soisalo, Mairi Kuris, Inga-Lill Svedberg, Sini Miettinen, Iina Vuoristo, Sini Karjalainen, Kati Kämpjärvi, Yilong Li, Miika Mehine, Tatiana Cajuso, and Felicia Wang for technical assistance. The authors also thank Dr Ian Tomlinson for providing some of the colorectal cancer cell lines used in this study.
References (15)
Gastroenterology
(2010)J Biol Chem
(2009)Biochem Biophys Res Commun
(2008)Biochem Biophys Res Commun
(2008)Biochem Biophys Res Commun
(2011)Cancer Res
(1998)Cancer Res
(2007)
Cited by (55)
MAS-related G protein-coupled receptors X (MRGPRX): Orphan GPCRs with potential as targets for future drugs
2022, Pharmacology and TherapeuticsCitation Excerpt :mRNA)MRGPRX4 was shown to be 6-fold higher in atherosclerotic arteries than in healthy samples and was identified to be one of the top 20 genes correlated with atherosclerosis (Evans et al., 2008). In 2013, an exome-screening approach of 25 colorectal tumors and respective healthy colon tissues identified MRGPRX4 as a potential oncogene (Gylfe et al., 2013). The human MRGPRX1 was the first receptor of the primate-specific subfamily for which an agonist, namely bovine adrenal medulla 8-22 peptide (BAM8-22), was identified (Lembo et al., 2002).
ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex
2021, International Journal of Biological MacromoleculesCitation Excerpt :Further studies describe ZBTB2 as a factor playing an important role in cell proliferation and report the involvement of this protein in the metabolic pathways regulating the expression of RelA/p65 [7]. In gastric cancer, targeting of ZBTB2 by microRNA-149 inhibits proliferation and cell cycle progression [8] and in human colorectal cancers, ZBTB2 shows hot spot mutations at Arg261 and Arg262 [9]. In oral squamous cell carcinoma, MiR-4282 inhibits tumor repression downregulating ZBTB2 expression [10] and in esophageal squamous carcinoma, microRNA-488-3p induces apoptosis by targeting ZBTB2 [11].
Microtubule associated protein 9 inhibits liver tumorigenesis by suppressing ERCC3
2020, EBioMedicineCitation Excerpt :MAPs exhibit a variety of functions implicated in influencing the dynamics of the microtubule cytoskeleton [5]. Recent studies indicated that alterations in MAPs are associated with human cancers [6–8]. MAP9, located on chromosome 4q32.1, is responsible for spindle assembly and cytokinesis [9], and enriched in vertebrate brain and testis tissues [10], but its deficiency gives rise to zebrafish embryo developmental defects [11].
A genetic variant in the immune-related gene ERAP1 affects colorectal cancer prognosis
2024, Chinese Medical JournalAggrephagy-related gene signature correlates with survival and tumor-associated macrophages in glioma: Insights from single-cell and bulk RNA sequencing
2024, Mathematical Biosciences and EngineeringDiscovery of Potent Agonists for the Predominant Variant of the Orphan MAS-Related G Protein-Coupled Receptor X4 (MRGPRX4)
2023, Journal of Medicinal Chemistry
Author names in bold designate shared co-first authorship.
Conflicts of interest The authors disclose no conflicts.
Funding Supported by grants from the Academy of Finland (Finnish Center of Excellence Program 2006-2011 and 2012-2017), The Finnish Cancer Society, The Sigrid Juselius Foundation, The Finnish Medical Society Duodecim, and The Cancer Foundation of Irja Karvonen. The Maud Kuistila Foundation, Finska Läkarsällskapet, The Biomedicum Helsinki Foundation, and Jalmari and Rauha Ahokas Foundation.
- ∗
Authors share co-first authorship.