Regular ArticleOpioids and food intake: distributed functional neural pathways?
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Meta-analysis of pre-clinical studies on the effects of opioid receptor ligands on food intake, motivation, and choice
2023, Neuroscience and Biobehavioral ReviewsStimulation of mu opioid, but not GABAergic, receptors of the lateral habenula alters free feeding in rats
2022, Neuroscience LettersCitation Excerpt :The inactivation condition directly tested our hypothesis that LHb activity may inhibit feeding, by examining whether its inactivation would disinhibit feeding behavior to promote intake. Additionally, μ-opioid receptors are distributed throughout both homeostatic and hedonic feeding circuitry of the brain, promote food intake [9,26–28], and are also highly expressed in the LHb [29]. We therefore also examined if the stimulation of mu-opioid receptors within the LHb might affect food intake on palatable and pabulum diets.
Potential roles for opioid receptors in motivation and major depressive disorder
2018, Progress in Brain ResearchOpioidergic and dopaminergic modulation of cost/benefit decision-making in Long Evans Rats
2017, Physiology and BehaviorCitation Excerpt :While some effects on primary motivation are possible, this does not appear to be the main variable affected. Opioid receptors are localized throughout hypothalamic brain sites that modulate homeostasis [55,63]. It should be noted, however, that Experiment 2 still differs from what has been observed with appetite manipulations, which decrease lever pressing and chow intake on the PR/Chow task and suppress consumption of both food options in no-effort conditions.