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Estrogen as neuroprotectant of nigrostriatal dopaminergic system

Laboratory and clinical studies

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Abstract

In this review, we relate both laboratory and clinical evidence associated with the capacity for estrogen to function as a modulator of nigrostriatal dopaminergic pathology. To accomplish this goal, we have divided this review into three parts. In Part 1, we provide a brief historical perspective of studies that have laid the groundwork for demonstrating the existence of hormonal-nigrostriatal interactions. In Part 2, we focus specifically on laboratory data that show the ability and conditions by which estrogen may function as a neuroprotectant of the nigrostriatal dopaminergic system. Finally, in Part 3, we review the clinical literature related to this issue as a means for consideration of estrogen as a modulator, neuroprotectant, and therapy for Parkinson disease.

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Authors and Affiliations

  1. Department of Neurology, University Medical Center-St. Radboud, Nijmegen, The Netherlands

    Martin W. I. M. Horstink

  2. Department of Anatomy, NEOUCOM, 4209 State Route 44, PO Box 95, 44272-0095, Rootstown, OH

    Dean E. Dluzen

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  1. Dean E. Dluzen
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  2. Martin W. I. M. Horstink
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Correspondence to Dean E. Dluzen.

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Dluzen, D.E., Horstink, M.W.I.M. Estrogen as neuroprotectant of nigrostriatal dopaminergic system. Endocr 21, 67–75 (2003). https://doi.org/10.1385/ENDO:21:1:67

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