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Critical Reviews™ in Eukaryotic Gene Expression

Published 6 issues per year

ISSN Print: 1045-4403

ISSN Online: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

The Nuclear Receptor PXR: A Master Regulator of “Homeland” Defense

Volume 12, Issue 1, 2002, 12 pages
DOI: 10.1615/CritRevEukaryotGeneExpr.v12.i1.30
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ABSTRACT

Human beings are constantly exposed to toxic chemicals present in food and the environment. We are also challenged by toxic byproducts of chemical reactions within our own bodies. These toxins need to be inactivated or excreted to maintain homeostasis. Pregnane X receptor (PXR) is a promiscuous nuclear receptor that is activated by a diverse array of endogenous and exogenous toxins. On activation, PXR regulates a number of target genes involved in drug metabolism and efflux in two key target tissues: the liver and intestine. In this article, we review the data accumulated in the last few years identifying PXR as a central player in the integration of these pathways.

CITED BY
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  4. Blumberg Bruce, Johnson Kameran, Hsu Tiffany, Tocotrienols Activate the Steroid and Xenobiotic Receptor SXR to Modulate Small Molecule Metabolism, in Tocotrienols, 2008. Crossref

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  6. Cavaco Isa, Gil J. Pedro, Gil-Berglund Eva, Ribeiro Vera, CYP3A4 and MDR1 Alleles in a Portuguese Population, Clinical Chemistry and Laboratory Medicine, 41, 10, 2003. Crossref

  7. Vadlapatla Ramya Krishna, Vadlapudi Aswani Dutt, Kwatra Deep, Pal Dhananjay, Mitra Ashim K., Differential effect of P-gp and MRP2 on cellular translocation of gemifloxacin, International Journal of Pharmaceutics, 420, 1, 2011. Crossref

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  23. Zucchini Nathalie, de Sousa Georges, Bailly-Maitre Béatrice, Gugenheim Jean, Bars Rémi, Lemaire Géraldine, Rahmani Roger, Regulation of Bcl-2 and Bcl-xL anti-apoptotic protein expression by nuclear receptor PXR in primary cultures of human and rat hepatocytes, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1745, 1, 2005. Crossref

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  26. Ott Melanie, Fricker Gert, Bauer Björn, Pregnane X Receptor (PXR) Regulates P-Glycoprotein at the Blood-Brain Barrier: Functional Similarities between Pig and Human PXR, Journal of Pharmacology and Experimental Therapeutics, 329, 1, 2009. Crossref

  27. Zhou Changcheng, Tabb Michelle M., Sadatrafiei Asal, Grün Felix, Blumberg Bruce, TOCOTRIENOLS ACTIVATE THE STEROID AND XENOBIOTIC RECEPTOR, SXR, AND SELECTIVELY REGULATE EXPRESSION OF ITS TARGET GENES, Drug Metabolism and Disposition, 32, 10, 2004. Crossref

  28. HARAIKAWA Mayu, SOGABE Natsuko, TANABE Rieko, HOSOI Takayuki, GOSEKI-SONE Masae, Vitamin K1 (Phylloquinone) or Vitamin K2 (Menaquinone-4) Induces Intestinal Alkaline Phosphatase Gene Expression, Journal of Nutritional Science and Vitaminology, 57, 4, 2011. Crossref

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  31. Zhou Changcheng, Poulton Emma-Jane, Grün Felix, Bammler Theo K., Blumberg Bruce, Thummel Kenneth E., Eaton David L., The Dietary Isothiocyanate Sulforaphane Is an Antagonist of the Human Steroid and Xenobiotic Nuclear Receptor, Molecular Pharmacology, 71, 1, 2007. Crossref

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