Abstract
Carcinogenesis results from the long-term accumulation of genetic and epigenetic aberrations at the molecular level, which are under constant selection pressure for growth advantage. Recognizing that cancer is the result of this long-term, multi-step process provides opportunities for molecularly targeted cancer prevention. Ideally, chemopreventive agents should be low in toxicity, morbidity, and cost. Several individual agents and agent combinations are currently under evaluation in the U.S. National Cancer Institutes (NCI) chemoprevention agent development program. Nonsteroidal anti-inflammatory drugs (NSAIDs) that inhibit cyclooxygenase (COX) -1 and -2 are among the most promising classes of agents for targeted molecular prevention.
Keywords: mf-tricyclio, colorectal carcinogenesis, apc, nin
Current Pharmaceutical Design
Title: The Role of Cyclooxygenase Inhibitors in Cancer Prevention
Volume: 8 Issue: 12
Author(s): William F. Anderson, Asad Umar, Jaye L. Viner and Ernest T. Hawk
Affiliation:
Keywords: mf-tricyclio, colorectal carcinogenesis, apc, nin
Abstract: Carcinogenesis results from the long-term accumulation of genetic and epigenetic aberrations at the molecular level, which are under constant selection pressure for growth advantage. Recognizing that cancer is the result of this long-term, multi-step process provides opportunities for molecularly targeted cancer prevention. Ideally, chemopreventive agents should be low in toxicity, morbidity, and cost. Several individual agents and agent combinations are currently under evaluation in the U.S. National Cancer Institutes (NCI) chemoprevention agent development program. Nonsteroidal anti-inflammatory drugs (NSAIDs) that inhibit cyclooxygenase (COX) -1 and -2 are among the most promising classes of agents for targeted molecular prevention.
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Cite this article as:
Anderson F. William, Umar Asad, Viner L. Jaye and Hawk T. Ernest, The Role of Cyclooxygenase Inhibitors in Cancer Prevention, Current Pharmaceutical Design 2002; 8 (12) . https://dx.doi.org/10.2174/1381612023394935
DOI https://dx.doi.org/10.2174/1381612023394935 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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