Transcriptional regulation: SWItching circuitry

Curr Biol. 1999 Mar 25;9(6):R221-4. doi: 10.1016/s0960-9822(99)80134-1.

Abstract

Proteins of the SWI/SNF family disrupt chromatin, hydrolysing ATP in the process. How they do so is still mysterious, but recent studies indicate that they can be targeted to the nuclear infrastructure and to particular genes, where they cooperate with other enzymes to activate or repress transcription.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Animals
  • Cell Nucleus / metabolism
  • Cell Nucleus / ultrastructure
  • Chromatin / metabolism
  • Chromatin / ultrastructure*
  • Chromosomal Proteins, Non-Histone
  • DNA Helicases
  • Drosophila Proteins*
  • Drosophila melanogaster / cytology
  • Drosophila melanogaster / genetics
  • Fungal Proteins / physiology
  • Gene Expression Regulation / physiology*
  • Insect Proteins / genetics
  • Insect Proteins / physiology
  • Mammals / genetics
  • Mammary Tumor Virus, Mouse / genetics
  • Models, Genetic
  • Multigene Family
  • Nuclear Proteins / genetics
  • Nuclear Proteins / physiology*
  • Promoter Regions, Genetic
  • RNA-Binding Proteins*
  • Receptors, Glucocorticoid / physiology
  • Ribonucleoprotein, U1 Small Nuclear / genetics
  • Ribonucleoprotein, U1 Small Nuclear / physiology*
  • Saccharomyces cerevisiae / cytology
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae Proteins
  • Transcription Factors / genetics
  • Transcription Factors / physiology*
  • Transcription, Genetic / physiology*

Substances

  • Chromatin
  • Chromosomal Proteins, Non-Histone
  • Drosophila Proteins
  • Fungal Proteins
  • Insect Proteins
  • Nuclear Proteins
  • RNA-Binding Proteins
  • Receptors, Glucocorticoid
  • Ribonucleoprotein, U1 Small Nuclear
  • SWI1 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Transcription Factors
  • snf protein, Drosophila
  • Adenosine Triphosphate
  • Smarca4 protein, mouse
  • DNA Helicases