Abstract
It was shown that the agonist of peripheral ORL1 receptors nociceptine raises heart resistance to the antiarrhythmic effect of aconitine. The antiarrhythmic effect of nociceptine is not connected with a change in the tonus of the autonomous nervous system or with an effect on opiate receptors. It is assumed that the antiarrhythmic properties of nociceptine are realized through inhibition of Na+/Ca2+ metabolism or blockade of rapid Na(+) channels of the cardiomyocytes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aconitine
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Animals
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Anti-Arrhythmia Agents / therapeutic use*
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Arrhythmias, Cardiac / chemically induced
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Arrhythmias, Cardiac / drug therapy
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Arrhythmias, Cardiac / physiopathology
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Calcium Chloride
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Disease Models, Animal
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Drug Evaluation, Preclinical
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Electrocardiography / drug effects
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Epinephrine
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Male
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Nociceptin
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Nociceptin Receptor
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Opioid Peptides / therapeutic use*
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Rats
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Rats, Wistar
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Receptors, Opioid / agonists*
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Time Factors
Substances
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Anti-Arrhythmia Agents
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Opioid Peptides
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Receptors, Opioid
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Calcium Chloride
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Aconitine
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Epinephrine
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Nociceptin Receptor
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Oprl protein, rat