Indinavir concentrations and St John's wort

Lancet. 2000 Feb 12;355(9203):547-8. doi: 10.1016/S0140-6736(99)05712-8.

Abstract

St John's wort reduced the area under the curve of the HIV-1 protease inhibitor indinavir by a mean of 57% (SD 19) and decreased the extrapolated 8-h indinavir trough by 81% (16) in healthy volunteers. A reduction in indinavir exposure of this magnitude could lead to the development of drug resistance and treatment failure.

Publication types

  • Clinical Trial
  • Letter

MeSH terms

  • Administration, Oral
  • Adult
  • Area Under Curve
  • Chromatography, High Pressure Liquid
  • Drug Resistance
  • Female
  • HIV Protease Inhibitors / administration & dosage
  • HIV Protease Inhibitors / antagonists & inhibitors
  • HIV Protease Inhibitors / pharmacokinetics*
  • Humans
  • Hypericum / adverse effects*
  • Indinavir / administration & dosage
  • Indinavir / antagonists & inhibitors
  • Indinavir / pharmacokinetics*
  • Male
  • Middle Aged
  • Plants, Medicinal*
  • Treatment Failure

Substances

  • HIV Protease Inhibitors
  • Indinavir