Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion

J H de Wilt; T L ten Hagen; G de Boeck; S T van Tiel; E A de Bruijn; A M Eggermont

doi:10.1054/bjoc.1999.1032

Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion

Br J Cancer. 2000 Mar;82(5):1000-3. doi: 10.1054/bjoc.1999.1032.

Authors

J H de Wilt¹, T L ten Hagen, G de Boeck, S T van Tiel, E A de Bruijn, A M Eggermont

Affiliation

¹ Department of Surgical Oncology, University Hospital Rotterdam Dijkzigt/Daniel den Hoed Cancer Centre, The Netherlands.

Abstract

Several possible mechanisms for the synergistic anti-tumour effects between tumour necrosis factor alpha (TNF-alpha) and melphalan after isolated limb perfusion (ILP) have been presented. We found a significant sixfold increase in melphalan tumour tissue concentration after ILP when TNF-alpha was added to the perfusate, which provides a straightforward explanation for the observed synergism between melphalan and TNF-alpha in ILP.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents, Alkylating / pharmacokinetics*
Disease Models, Animal
Drug Synergism
Extremities
Male
Melphalan / pharmacokinetics*
Neoplasm Transplantation
Neoplasms, Experimental / metabolism*
Perfusion
Rats
Rats, Inbred BN
Tumor Necrosis Factor-alpha / pharmacology*

Substances

Antineoplastic Agents, Alkylating
Tumor Necrosis Factor-alpha
Melphalan