Abstract
Knockout mice lacking the P2X(1) receptor appear normal, but fail to breed. Analysis of these mutant mice clearly shows that purinergic co-transmission has a physiological role in the was deferens. These findings also raise the possibility of developing non-hormonal ways of regulating male fertility.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adenosine Triphosphate / analogs & derivatives
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Adenosine Triphosphate / pharmacology
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Adrenergic alpha-Antagonists / pharmacology
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Animals
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Contraceptive Agents, Male / pharmacology
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Drug Design
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Electric Stimulation
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Fertility / genetics*
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Humans
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Male
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Mice
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Mice, Knockout
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Prazosin / pharmacology
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Receptors, Purinergic P2 / deficiency
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Receptors, Purinergic P2 / drug effects
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Receptors, Purinergic P2 / genetics*
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Receptors, Purinergic P2X
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Vas Deferens / physiology*
Substances
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Adrenergic alpha-Antagonists
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Contraceptive Agents, Male
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Receptors, Purinergic P2
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Receptors, Purinergic P2X
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Adenosine Triphosphate
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alpha,beta-methyleneadenosine 5'-triphosphate
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Prazosin