Abstract
Systemic subchronic oxytocin treatment significantly and substantially increased the B(max) values of the alpha 2 agonist [(3)H]UK14.304 binding sites in the hypothalamus, the amygdala and the paraventricular thalamic nucleus of the rat as shown by quantitative receptor autoradiography. These results suggest that long-term modulation of autonomic and neuroendocrine functions and emotional behaviours elicited by brain oxytocin may involve enhancement of central alpha 2-adrenoceptor function.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adrenergic alpha-Agonists / pharmacokinetics
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Amygdala / physiology
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Animals
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Autoradiography
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Brimonidine Tartrate
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Diencephalon / drug effects
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Diencephalon / physiology*
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Hypothalamus / physiology
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Male
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Oxytocin / administration & dosage
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Oxytocin / pharmacology*
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Paraventricular Hypothalamic Nucleus / physiology
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Quinoxalines / pharmacokinetics
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Rats
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Rats, Sprague-Dawley
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Receptors, Adrenergic, alpha-2 / drug effects
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Receptors, Adrenergic, alpha-2 / physiology*
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Telencephalon / drug effects
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Telencephalon / physiology*
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Tritium
Substances
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Adrenergic alpha-Agonists
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Quinoxalines
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Receptors, Adrenergic, alpha-2
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Tritium
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Brimonidine Tartrate
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Oxytocin