Does CDP-choline modulate phospholipase activities after transient forebrain ischemia?

Brain Res. 2001 Mar 2;893(1-2):268-72. doi: 10.1016/s0006-8993(00)03280-7.

Abstract

Ten min forebrain ischemia/1-day reperfusion resulted in significant decreases in total phosphatidylcholine (PtdCho), phosphatidylinositol (PtdIns), and cardiolipin in gerbil hippocampus. CDP-choline restored cardiolipin levels, arachidonic acid content of PtdCho, partially but significantly restored total PtdCho, and had no effect on PtdIns. These data suggest that CDP-choline prevented the activation of phospholipase A(2) (rather than inhibiting phospholipase A(2) activity) but did not affect activities of PtdCho-phospholipases C and/or D, or phosphoinositide-phospholipase C. CDP-choline also provided significant protection for hippocampal CA(1) neurons.

MeSH terms

  • Animals
  • Arachidonic Acid / metabolism
  • Cardiolipins / chemistry
  • Cardiolipins / metabolism
  • Cytidine Diphosphate Choline / administration & dosage*
  • Disease Models, Animal
  • Enzyme Activation / drug effects
  • Fatty Acids / analysis
  • Fatty Acids / metabolism
  • Gerbillinae
  • Hippocampus / drug effects
  • Hippocampus / metabolism
  • Injections, Intraperitoneal
  • Ischemic Attack, Transient / metabolism*
  • Isoenzymes / metabolism
  • Male
  • Nootropic Agents / administration & dosage*
  • Phosphatidylcholines / chemistry
  • Phosphatidylcholines / metabolism
  • Phosphatidylinositols / chemistry
  • Phosphatidylinositols / metabolism
  • Phospholipase D / metabolism
  • Phospholipases / metabolism*
  • Phospholipases A / metabolism
  • Prosencephalon / blood supply
  • Prosencephalon / metabolism*
  • Type C Phospholipases / metabolism

Substances

  • Cardiolipins
  • Fatty Acids
  • Isoenzymes
  • Nootropic Agents
  • Phosphatidylcholines
  • Phosphatidylinositols
  • Arachidonic Acid
  • Cytidine Diphosphate Choline
  • Phospholipases
  • Phospholipases A
  • Type C Phospholipases
  • Phospholipase D