Abstract
Ten min forebrain ischemia/1-day reperfusion resulted in significant decreases in total phosphatidylcholine (PtdCho), phosphatidylinositol (PtdIns), and cardiolipin in gerbil hippocampus. CDP-choline restored cardiolipin levels, arachidonic acid content of PtdCho, partially but significantly restored total PtdCho, and had no effect on PtdIns. These data suggest that CDP-choline prevented the activation of phospholipase A(2) (rather than inhibiting phospholipase A(2) activity) but did not affect activities of PtdCho-phospholipases C and/or D, or phosphoinositide-phospholipase C. CDP-choline also provided significant protection for hippocampal CA(1) neurons.
MeSH terms
-
Animals
-
Arachidonic Acid / metabolism
-
Cardiolipins / chemistry
-
Cardiolipins / metabolism
-
Cytidine Diphosphate Choline / administration & dosage*
-
Disease Models, Animal
-
Enzyme Activation / drug effects
-
Fatty Acids / analysis
-
Fatty Acids / metabolism
-
Gerbillinae
-
Hippocampus / drug effects
-
Hippocampus / metabolism
-
Injections, Intraperitoneal
-
Ischemic Attack, Transient / metabolism*
-
Isoenzymes / metabolism
-
Male
-
Nootropic Agents / administration & dosage*
-
Phosphatidylcholines / chemistry
-
Phosphatidylcholines / metabolism
-
Phosphatidylinositols / chemistry
-
Phosphatidylinositols / metabolism
-
Phospholipase D / metabolism
-
Phospholipases / metabolism*
-
Phospholipases A / metabolism
-
Prosencephalon / blood supply
-
Prosencephalon / metabolism*
-
Type C Phospholipases / metabolism
Substances
-
Cardiolipins
-
Fatty Acids
-
Isoenzymes
-
Nootropic Agents
-
Phosphatidylcholines
-
Phosphatidylinositols
-
Arachidonic Acid
-
Cytidine Diphosphate Choline
-
Phospholipases
-
Phospholipases A
-
Type C Phospholipases
-
Phospholipase D