Abstract
The general anesthetics, nitrous oxide (N(2)O) and ketamine, are NMDA antagonists which, like other NMDA antagonists such as MK801, induce a neurotoxic reaction in the rat brain. For MK801 neurotoxicity, both age and sex are important variables (adult rats are more sensitive than immature rats and females are more sensitive than males). In this study we found that ketamine has this same age and sex dependency profile, and N(2)O has the same age but not sex dependency. Male and female rats are equally sensitive to N(2)O neurotoxicity.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Age Factors
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Analgesics, Non-Narcotic / pharmacology*
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Anesthetics, Dissociative / pharmacology*
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Animals
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Animals, Newborn
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Cerebral Cortex / drug effects*
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Cerebral Cortex / metabolism
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Cerebral Cortex / pathology
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Dose-Response Relationship, Drug
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Excitatory Amino Acid Antagonists / toxicity
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Female
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Ketamine / toxicity*
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Male
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Neurons / drug effects*
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Neurons / metabolism
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Neurons / pathology
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Neurotoxins / toxicity*
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Nitrous Oxide / toxicity*
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Rats
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Rats, Sprague-Dawley
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Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors
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Receptors, N-Methyl-D-Aspartate / metabolism
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Sex Factors
Substances
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Analgesics, Non-Narcotic
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Anesthetics, Dissociative
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Excitatory Amino Acid Antagonists
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Neurotoxins
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Receptors, N-Methyl-D-Aspartate
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Ketamine
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Nitrous Oxide