Discovery and optimization of a novel series of thrombin receptor (par-1) antagonists: potent, selective peptide mimetics based on indole and indazole templates

J Med Chem. 2001 Mar 29;44(7):1021-4. doi: 10.1021/jm000506s.
No abstract available

MeSH terms

  • Angioplasty, Balloon
  • Animals
  • Constriction, Pathologic
  • Fibrinolytic Agents / chemical synthesis*
  • Fibrinolytic Agents / chemistry
  • Fibrinolytic Agents / pharmacology
  • Guinea Pigs
  • Indazoles / chemical synthesis*
  • Indazoles / chemistry
  • Indazoles / pharmacology
  • Indoles / chemical synthesis*
  • Indoles / chemistry
  • Indoles / pharmacology
  • Molecular Mimicry
  • Muscle, Smooth / drug effects
  • Muscle, Smooth / pathology
  • Rats
  • Receptor, PAR-1
  • Receptors, Thrombin / antagonists & inhibitors*
  • Structure-Activity Relationship
  • Urea / analogs & derivatives
  • Urea / chemical synthesis*
  • Urea / chemistry
  • Urea / pharmacology

Substances

  • Fibrinolytic Agents
  • Indazoles
  • Indoles
  • RWJ 58259
  • Receptor, PAR-1
  • Receptors, Thrombin
  • Urea