Failure of the ubiquitin-proteasome system in Parkinson's disease

Nat Rev Neurosci. 2001 Aug;2(8):589-94. doi: 10.1038/35086067.

Authors

K S McNaught¹, C W Olanow, B Halliwell, O Isacson, P Jenner

Affiliation

¹ Neuroregeneration Laboratory, Harvard Medical School and McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA. kevin.mcnaught@mclean.harvard.edu

PMID: 11484002
DOI: 10.1038/35086067

No abstract available

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Animals
Cysteine Endopeptidases / genetics
Cysteine Endopeptidases / metabolism*
Humans
Lewy Bodies / genetics
Lewy Bodies / metabolism
Lewy Bodies / pathology
Multienzyme Complexes / genetics
Multienzyme Complexes / metabolism*
Nerve Tissue Proteins / genetics
Nerve Tissue Proteins / metabolism
Parkinson Disease / metabolism*
Parkinson Disease / pathology
Parkinson Disease / physiopathology
Peptide Hydrolases / genetics
Peptide Hydrolases / metabolism
Proteasome Endopeptidase Complex
Substantia Nigra / metabolism*
Substantia Nigra / pathology
Substantia Nigra / physiopathology
Ubiquitins / genetics
Ubiquitins / metabolism*

Substances

Multienzyme Complexes
Nerve Tissue Proteins
Ubiquitins
Peptide Hydrolases
Cysteine Endopeptidases
Proteasome Endopeptidase Complex