Abstract
Quantitative in situ hybridization on rat coronal brain sections with radiolabelled oligonucleotide probes was performed to investigate the effects of antipsychotic drugs on mRNA levels of regulator of G-protein signalling (RGS) 2 and c-fos. This study demonstrated a similar increase of RGS2 mRNA level in the striatum upon both a single and a 21-day treatment with either haloperidol (2 mg/kg) or risperidone (7.5 mg/kg) in contrast to clozapine (20 mg/kg). Otherwise, the acute c-fos mRNA induction in the striatum was abolished by 74 to 89% upon chronic treatment with either haloperidol or risperidone. In conclusion, the induction of RGS2 mRNA in the striatum, in contrast to the immediate early gene c-fos mRNA, is preserved upon chronic treatment with haloperidol and risperidone.
MeSH terms
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Animals
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Antipsychotic Agents / pharmacology*
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Clozapine / pharmacology
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Drug Administration Schedule
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GTP-Binding Proteins / drug effects
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GTP-Binding Proteins / metabolism
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Haloperidol / pharmacology
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In Situ Hybridization
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Male
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Neostriatum / drug effects*
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Neostriatum / metabolism
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Neurons / drug effects*
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Neurons / metabolism
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Proto-Oncogene Proteins c-fos / genetics*
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RGS Proteins / genetics*
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RNA, Messenger / drug effects*
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RNA, Messenger / metabolism
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Rats
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Rats, Wistar
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Risperidone / pharmacology
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Signal Transduction / drug effects
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Signal Transduction / genetics
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Up-Regulation / drug effects*
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Up-Regulation / genetics
Substances
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Antipsychotic Agents
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Proto-Oncogene Proteins c-fos
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RGS Proteins
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RNA, Messenger
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Rgs2 protein, mouse
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GTP-Binding Proteins
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Clozapine
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Haloperidol
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Risperidone