Abstract
The study investigated the role of nitric oxide (NO) in the relapse to drug-seeking behavior induced by D-methamphetamine. After the induction of D-methamphetamine (1 mg/kg) conditioned place preference, the rewarding effect became extinct 6 weeks later. The extinguished place preference was reinstated by D-methamphetamine (0.125 mg/kg) injection, an effect which was attenuated by 7-nitroindazole (12.5 and 25 mg/kg) pretreatment. The results demonstrate that NO is involved in relapse primed by D-methamphetamine injection.
MeSH terms
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Amphetamine-Related Disorders / psychology*
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Animals
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Conditioning, Psychological / drug effects*
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Homing Behavior / drug effects
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Indazoles / pharmacology*
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Male
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Methamphetamine / administration & dosage
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Methamphetamine / chemistry
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Methamphetamine / pharmacology*
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Nitric Oxide / physiology
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Nitric Oxide Synthase / antagonists & inhibitors*
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Nitric Oxide Synthase Type I
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Rats
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Rats, Sprague-Dawley
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Recurrence
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Stereoisomerism
Substances
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Indazoles
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Nitric Oxide
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Methamphetamine
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Nitric Oxide Synthase
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Nitric Oxide Synthase Type I
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Nos1 protein, rat
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7-nitroindazole