Abstract
Circadian rhythms are generated by a transcription/translation feedback loop consisting of two limbs, one positive and one negative. The nuclear orphan receptor, REV-ERBalpha, is identified as a molecular link coupling these two limbs.
MeSH terms
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Animals
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Biological Clocks / genetics*
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Circadian Rhythm / genetics*
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DNA-Binding Proteins*
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Feedback / physiology*
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Humans
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Mice
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Mice, Knockout / genetics
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Mice, Knockout / metabolism*
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Nuclear Receptor Subfamily 1, Group D, Member 1
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Protein Biosynthesis / genetics*
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Proteins / genetics
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Proteins / metabolism*
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Receptors, Cytoplasmic and Nuclear*
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Transcription Factors / genetics
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Transcription, Genetic / genetics*
Substances
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DNA-Binding Proteins
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NR1D1 protein, human
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Nr1d1 protein, mouse
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Nuclear Receptor Subfamily 1, Group D, Member 1
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Proteins
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Receptors, Cytoplasmic and Nuclear
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Transcription Factors