REV-ving up the clock

Dev Cell. 2002 Aug;3(2):150-2. doi: 10.1016/s1534-5807(02)00225-3.

Abstract

Circadian rhythms are generated by a transcription/translation feedback loop consisting of two limbs, one positive and one negative. The nuclear orphan receptor, REV-ERBalpha, is identified as a molecular link coupling these two limbs.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Clocks / genetics*
  • Circadian Rhythm / genetics*
  • DNA-Binding Proteins*
  • Feedback / physiology*
  • Humans
  • Mice
  • Mice, Knockout / genetics
  • Mice, Knockout / metabolism*
  • Nuclear Receptor Subfamily 1, Group D, Member 1
  • Protein Biosynthesis / genetics*
  • Proteins / genetics
  • Proteins / metabolism*
  • Receptors, Cytoplasmic and Nuclear*
  • Transcription Factors / genetics
  • Transcription, Genetic / genetics*

Substances

  • DNA-Binding Proteins
  • NR1D1 protein, human
  • Nr1d1 protein, mouse
  • Nuclear Receptor Subfamily 1, Group D, Member 1
  • Proteins
  • Receptors, Cytoplasmic and Nuclear
  • Transcription Factors