Abstract
Repeated administration of cocaine lowers the basal extracellular levels of glutamate in the nucleus accumbens as measured by microdialysis. The studies presented reveal that this long-term neuroadaptation elicited by repeated cocaine results from a decrease in the activity of cystine/glutamate exchange.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Biological Transport / drug effects
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Biological Transport / physiology
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Calcium Channel Blockers / pharmacology
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Cocaine / administration & dosage
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Cocaine / pharmacology*
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Cystine / metabolism*
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Diltiazem / pharmacology
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Dopamine Uptake Inhibitors / administration & dosage
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Dopamine Uptake Inhibitors / pharmacology*
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Glutamic Acid / metabolism*
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Microdialysis
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Nucleus Accumbens / drug effects*
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Nucleus Accumbens / metabolism
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Rats
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Tetrodotoxin / pharmacology
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omega-Conotoxins / pharmacology
Substances
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Calcium Channel Blockers
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Dopamine Uptake Inhibitors
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omega-Conotoxins
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Glutamic Acid
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Tetrodotoxin
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Cystine
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Diltiazem
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Cocaine