Abstract
A high-resolution X-ray crystal structure of the retinoic acid receptor-related orphan receptor (RORalpha; NR1F1), which reveals a molecule of cholesterol within the ligand binding pocket, is a breakthrough in functional analysis of this orphan nuclear receptor.
MeSH terms
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Cholesterol / chemistry*
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Cholesterol / metabolism
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Crystallography, X-Ray
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Ligands
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Nuclear Receptor Subfamily 1, Group F, Member 1
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Protein Conformation
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Receptors, Cytoplasmic and Nuclear / chemistry*
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Receptors, Cytoplasmic and Nuclear / metabolism
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Trans-Activators / chemistry*
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Trans-Activators / metabolism
Substances
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Ligands
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Nuclear Receptor Subfamily 1, Group F, Member 1
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Receptors, Cytoplasmic and Nuclear
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Trans-Activators
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Cholesterol