Abstract
Two nuclear receptors of xenobiotic drugs, PXR and CAR, are central regulators of detoxification enzymes. New studies extend the role of these receptors to a natural detoxification process. They coordinate induction of proteins for storage, glucuronidation, and canalicular transport of bilirubin.
MeSH terms
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Animals
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Bilirubin / metabolism
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Constitutive Androstane Receptor
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Glucuronosyltransferase / metabolism
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Humans
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Inactivation, Metabolic
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Pregnane X Receptor
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Receptors, Cytoplasmic and Nuclear / metabolism*
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Receptors, Steroid / metabolism*
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Transcription Factors / metabolism*
Substances
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Constitutive Androstane Receptor
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Pregnane X Receptor
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Receptors, Cytoplasmic and Nuclear
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Receptors, Steroid
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Transcription Factors
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UGT1A1 enzyme
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Glucuronosyltransferase
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Bilirubin