Abstract
Three new neoclerodane diterpenoids, salvinorins D-F (4-6), have been isolated from the leaves of Salvia divinorum. The structures were elucidated by chemical and spectroscopic methods, particularly 1D and 2D NMR. A simplified isolation method using chromatography on activated carbon also gave improved yields of the controlled substance salvinorin A (1) and of salvinorin C (3).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylation
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Animals
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Diterpenes / chemistry
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology
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Diterpenes, Clerodane
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Feeding Behavior / drug effects
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Mexico
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Salvia / chemistry*
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Spodoptera / drug effects
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Tenebrio / drug effects
Substances
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Diterpenes
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Diterpenes, Clerodane
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salvinorin D
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salvinorin E
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salvinorin F