Effects of interleukin-1 receptor antagonist on the behavioral effects of lipopolysaccharide in rat

Brain Res. 1992 Feb 28;573(2):318-20. doi: 10.1016/0006-8993(92)90779-9.

Abstract

To investigate the role of interleukin-1 (IL-1) in lipopolysaccharide (LPS)-induced sickness behavior, rats were injected with recombinant human interleukin-1 receptor antagonist (IL-1ra), an endogenous cytokine able to block most of the biological effects of IL-1 both in vivo and in vitro. Intraperitoneal injection of IL-1ra (3 mg/rat) attenuated the depressive effect of LPS (250 micrograms/kg) on social exploration and body weight when both treatments were injected peripherally. Intracerebroventricular injection of IL-1ra (60 micrograms/rat) did not block the effects of peripherally injected LPS. These data indicate that the peripherally mediated effects of IL-1 account for a significant part of LPS-induced sickness behavior.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Body Weight / drug effects
  • Cerebral Ventricles / drug effects
  • Cerebral Ventricles / physiology*
  • Exploratory Behavior / drug effects*
  • Injections, Intraventricular
  • Interleukins / administration & dosage
  • Interleukins / pharmacology*
  • Interleukins / physiology
  • Lipopolysaccharides / toxicity*
  • Male
  • Rats
  • Rats, Inbred Strains
  • Receptors, Immunologic / antagonists & inhibitors*
  • Receptors, Interleukin-1
  • Reference Values

Substances

  • Interleukins
  • Lipopolysaccharides
  • Receptors, Immunologic
  • Receptors, Interleukin-1