Divinatorins A-C, new neoclerodane diterpenoids from the controlled sage Salvia divinorum

Andrea K Bigham; Thomas A Munro; Mark A Rizzacasa; Roy M Robins-Browne

doi:10.1021/np030313i

Divinatorins A-C, new neoclerodane diterpenoids from the controlled sage Salvia divinorum

J Nat Prod. 2003 Sep;66(9):1242-4. doi: 10.1021/np030313i.

Authors

Andrea K Bigham¹, Thomas A Munro, Mark A Rizzacasa, Roy M Robins-Browne

Affiliation

¹ Department of Microbiology and Immunology, School of Chemistry, The University of Melbourne, Victoria, 3010, Australia.

PMID: 14510607
DOI: 10.1021/np030313i

Abstract

Three new neoclerodane diterpenoids, divinatorins A-C (7-9), have been isolated from the leaves of Salvia divinorum. The compounds were identified by spectroscopic methods as derivatives of the antibiotic (-)-hardwickiic acid (10), which was also isolated, along with four other known terpenoids. Neither the crude extract nor 7-9 displayed antimicrobial activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Infective Agents / chemistry
Anti-Infective Agents / isolation & purification*
Anti-Infective Agents / pharmacology
Australia
Diterpenes / chemistry
Diterpenes, Clerodane / chemistry
Diterpenes, Clerodane / isolation & purification*
Diterpenes, Clerodane / pharmacology
Microbial Sensitivity Tests
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plant Leaves / chemistry
Plants, Medicinal / chemistry*
Salvia / chemistry*

Substances

Anti-Infective Agents
Diterpenes
Diterpenes, Clerodane
divinatorin A
divinatorin B
divinatorin C
hardwickic acid