Abstract
Cyclo-oxygenase (COX)-2 is induced in various types of cancer tissues. Here, we demonstrate stromal expression of both COX-2 and microsomal prostaglandin E(2) synthase (mPGES)-1 in gastrointestinal hamartomas developed in Lkb1(+/-), Smad4(+/-) and Cdx2(+/-)mice. These results suggest that PGE(2) produced by COX-2 and mPGES-1 plays an important role in hamartoma development regardless of the mutated genes causing hamartomas.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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AMP-Activated Protein Kinases
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Adaptor Proteins, Signal Transducing
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Animals
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CDX2 Transcription Factor
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Carrier Proteins*
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Cyclooxygenase 2
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DNA-Binding Proteins / genetics
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Genes, Tumor Suppressor
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Hamartoma / genetics*
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Hamartoma / pathology
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Hamartoma / veterinary
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Homeodomain Proteins / genetics
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Immunohistochemistry
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Intracellular Signaling Peptides and Proteins
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Intramolecular Oxidoreductases / biosynthesis*
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Intramolecular Oxidoreductases / genetics
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Isoenzymes / biosynthesis*
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Isoenzymes / genetics
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Mice
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Peroxidases / biosynthesis
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Prostaglandin-E Synthases
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Prostaglandin-Endoperoxide Synthases / biosynthesis*
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Prostaglandin-Endoperoxide Synthases / genetics
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Protein Serine-Threonine Kinases
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Signal Transduction
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Smad4 Protein
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Stomach Diseases / genetics*
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Stomach Diseases / pathology
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Stomach Diseases / veterinary
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Trans-Activators / genetics
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Transforming Growth Factor beta
Substances
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Adaptor Proteins, Signal Transducing
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CDX2 Transcription Factor
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Carrier Proteins
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DNA-Binding Proteins
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Homeodomain Proteins
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Intracellular Signaling Peptides and Proteins
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Isoenzymes
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Smad4 Protein
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Smad4 protein, mouse
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Stk11ip protein, mouse
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Trans-Activators
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Transforming Growth Factor beta
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Peroxidases
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Cyclooxygenase 2
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Prostaglandin-Endoperoxide Synthases
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Protein Serine-Threonine Kinases
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Stk11 protein, mouse
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AMP-Activated Protein Kinases
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Intramolecular Oxidoreductases
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Prostaglandin-E Synthases
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Ptges protein, mouse