Abstract
Hypocretin-1 is involved in the regulation of the sleep-wake cycle. The authors prospectively assessed CSF hypocretin-1 levels in 44 consecutive patients with acute traumatic brain injury (TBI). Compared with controls, hypocretin-1 levels were abnormally lower in 95% of patients with moderate to severe TBI and in 97% of patients with posttraumatic brain CT changes. Hypocretin-1 deficiency after TBI may reflect hypothalamic damage and be linked with the frequent development of posttraumatic sleep-wake disorders.
MeSH terms
-
Adolescent
-
Adult
-
Aged
-
Autonomic Nervous System / metabolism
-
Autonomic Nervous System / physiopathology
-
Body Temperature / physiology
-
Brain Injuries / cerebrospinal fluid
-
Brain Injuries / complications*
-
Brain Injuries / physiopathology
-
Female
-
Humans
-
Hypothalamic Area, Lateral / metabolism
-
Hypothalamic Area, Lateral / physiopathology
-
Hypothalamic Diseases / cerebrospinal fluid
-
Hypothalamic Diseases / etiology*
-
Hypothalamic Diseases / physiopathology
-
Hypothalamus / metabolism
-
Hypothalamus / physiopathology*
-
Hypothalamus, Posterior / metabolism
-
Hypothalamus, Posterior / physiopathology
-
Intracellular Signaling Peptides and Proteins / cerebrospinal fluid
-
Intracellular Signaling Peptides and Proteins / deficiency
-
Intracellular Signaling Peptides and Proteins / metabolism*
-
Male
-
Middle Aged
-
Neural Pathways / metabolism
-
Neural Pathways / physiopathology
-
Neuropeptides / cerebrospinal fluid
-
Neuropeptides / deficiency
-
Neuropeptides / metabolism*
-
Orexins
-
Prospective Studies
-
Sleep / physiology
-
Sleep Wake Disorders / cerebrospinal fluid
-
Sleep Wake Disorders / etiology*
-
Sleep Wake Disorders / physiopathology
-
Wakefulness / physiology
Substances
-
HCRT protein, human
-
Intracellular Signaling Peptides and Proteins
-
Neuropeptides
-
Orexins