A genomic and functional inventory of deubiquitinating enzymes

Sebastian M B Nijman; Mark P A Luna-Vargas; Arno Velds; Thijn R Brummelkamp; Annette M G Dirac; Titia K Sixma; René Bernards

doi:10.1016/j.cell.2005.11.007

A genomic and functional inventory of deubiquitinating enzymes

Cell. 2005 Dec 2;123(5):773-86. doi: 10.1016/j.cell.2005.11.007.

Authors

Sebastian M B Nijman¹, Mark P A Luna-Vargas, Arno Velds, Thijn R Brummelkamp, Annette M G Dirac, Titia K Sixma, René Bernards

Affiliation

¹ Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. s.nijman@nki.nl

PMID: 16325574
DOI: 10.1016/j.cell.2005.11.007

Abstract

Posttranslational modification of proteins by the small molecule ubiquitin is a key regulatory event, and the enzymes catalyzing these modifications have been the focus of many studies. Deubiquitinating enzymes, which mediate the removal and processing of ubiquitin, may be functionally as important but are less well understood. Here, we present an inventory of the deubiquitinating enzymes encoded in the human genome. In addition, we review the literature concerning these enzymes, with particular emphasis on their function, specificity, and the regulation of their activity.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Amino Acid Motifs
Animals
Chromatin / chemistry
Chromatin / metabolism
Endocytosis / physiology
Endopeptidases* / chemistry
Endopeptidases* / classification
Endopeptidases* / genetics
Endopeptidases* / metabolism
Genome, Human*
Humans
Hydrolases* / chemistry
Hydrolases* / classification
Hydrolases* / genetics
Hydrolases* / metabolism
Models, Molecular
Phylogeny
Proteasome Endopeptidase Complex / metabolism
Protein Conformation
Protein Processing, Post-Translational
Substrate Specificity
Ubiquitin / metabolism*

Substances

Chromatin
Ubiquitin
Hydrolases
Endopeptidases
Proteasome Endopeptidase Complex