Abstract
Somatic hypermutation and class-switch-recombination are initiated by the deamination of deoxycytosine in DNA by activation-induced-deaminase, AID. Recently, there has been much research into how AID targets double-stranded DNA in sub-regions of Ig genes, the involvement of co-factors and posttranslational modifications in this process, the co-option of DNA 'repair' mechanisms and AID evolution.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cytidine Deaminase / genetics
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Cytidine Deaminase / immunology*
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DNA / immunology
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Humans
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Immunoglobulin Class Switching*
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Immunoglobulin Switch Region / genetics
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Models, Immunological
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Recombination, Genetic*
Substances
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DNA
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AICDA (activation-induced cytidine deaminase)
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Cytidine Deaminase