Abstract
Belimumab, the lead in a series of human monoclonal antibodies against the human protein B-lymphocyte stimulator (BLyS), is under development by Human Genome Sciences, Cambridge Antibody Technology and GlaxoSmithKline for the potential treatment of autoimmune diseases, including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). By January 2006, belimumab had completed phase II clinical trials in SLE and RA; a phase III clinical SLE trial is scheduled to begin later this year.
MeSH terms
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Adult
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Animals
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Antibodies, Monoclonal / administration & dosage
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Antibodies, Monoclonal / pharmacokinetics
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Antibodies, Monoclonal / therapeutic use*
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Antibodies, Monoclonal, Humanized
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Arthritis, Rheumatoid / drug therapy*
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B-Cell Activating Factor
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Drug Administration Schedule
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Drug Evaluation, Preclinical
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Female
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Humans
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Immunologic Factors / administration & dosage
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Immunologic Factors / therapeutic use*
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Infusions, Intravenous
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Lupus Erythematosus, Systemic / drug therapy*
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Membrane Proteins / immunology
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Middle Aged
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Patents as Topic
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Randomized Controlled Trials as Topic
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Tumor Necrosis Factor-alpha / immunology
Substances
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Antibodies, Monoclonal
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Antibodies, Monoclonal, Humanized
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B-Cell Activating Factor
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Immunologic Factors
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Membrane Proteins
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TNFSF13B protein, human
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Tumor Necrosis Factor-alpha
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belimumab