Abstract
The intrahypothalamic injection of rat amylin reduced feeding in schedule-fed rats for eight hours. Specificity of this anorectic response was indicated by an appropriate dose-response relationship and the absence of effect of human amylin. Amylin-induced anorexia was accompanied by alterations in neurotransmitter metabolism similar to those observed in anorectic tumor-bearing rats. These results indicate that amylin may inhibit feeding by acting directly on hypothalamic neurons to alter metabolism of neurotransmitter systems known to affect feeding behavior.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amyloid / administration & dosage
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Amyloid / cerebrospinal fluid
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Amyloid / pharmacology*
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Animals
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Appetite Depressants*
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Brain Chemistry / drug effects
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Calcitonin Gene-Related Peptide / pharmacology
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Dose-Response Relationship, Drug
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Eating / drug effects
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Humans
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Hypothalamus
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Injections
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Islet Amyloid Polypeptide
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Male
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Neurotransmitter Agents / metabolism
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Rats
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Rats, Inbred Strains
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Species Specificity
Substances
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Amyloid
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Appetite Depressants
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Islet Amyloid Polypeptide
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Neurotransmitter Agents
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Calcitonin Gene-Related Peptide