Ion trap tandem mass spectrometric evidence for the metabolism of 3,4-(methylenedioxy)methamphetamine to the potent neurotoxins 2,4,5-trihydroxymethamphetamine and 2,4,5-trihydroxyamphetamine

Chem Res Toxicol. 1991 Nov-Dec;4(6):626-32. doi: 10.1021/tx00024a004.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 3,4-Methylenedioxyamphetamine / analogs & derivatives*
  • 3,4-Methylenedioxyamphetamine / metabolism
  • 3,4-Methylenedioxyamphetamine / toxicity
  • Amphetamines / metabolism
  • Amphetamines / toxicity
  • Animals
  • Cytochrome P-450 Enzyme System / physiology
  • In Vitro Techniques
  • Liver / metabolism
  • Male
  • Mass Spectrometry
  • Methamphetamine / analogs & derivatives*
  • Methamphetamine / metabolism
  • Methamphetamine / toxicity
  • N-Methyl-3,4-methylenedioxyamphetamine
  • Nervous System / drug effects*
  • Rats
  • Rats, Inbred Strains

Substances

  • Amphetamines
  • 2,4,5-trihydroxymethamphetamine
  • 2,4,5-trihydroxyamphetamine
  • Methamphetamine
  • 3,4-Methylenedioxyamphetamine
  • Cytochrome P-450 Enzyme System
  • N-Methyl-3,4-methylenedioxyamphetamine