Abstract
Subpopulations of RNA molecules that bind specifically to a variety of organic dyes have been isolated from a population of random sequence RNA molecules. Roughly one in 10(10) random sequence RNA molecules folds in such a way as to create a specific binding site for small ligands.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Base Sequence
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Binding Sites
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Chromatography, Affinity
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Cloning, Molecular
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Coloring Agents / metabolism*
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DNA / chemical synthesis
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Ligands
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Molecular Sequence Data
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Molecular Structure
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Nucleic Acid Conformation
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Polymerase Chain Reaction
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RNA / biosynthesis
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RNA / isolation & purification*
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RNA / metabolism
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Templates, Genetic
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Transcription, Genetic
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Triazines / metabolism
Substances
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Coloring Agents
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Ligands
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Triazines
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procion blue MX-R
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Cibacron Blue F 3GA
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RNA
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DNA