Involvement of the bed nucleus of the stria terminalis in the negative affective component of visceral and somatic pain in rats

Satoshi Deyama; Takayuki Nakagawa; Shuji Kaneko; Takashi Uehara; Masabumi Minami

doi:10.1016/j.bbr.2006.10.021

Involvement of the bed nucleus of the stria terminalis in the negative affective component of visceral and somatic pain in rats

Behav Brain Res. 2007 Jan 25;176(2):367-71. doi: 10.1016/j.bbr.2006.10.021. Epub 2006 Nov 13.

Authors

Satoshi Deyama¹, Takayuki Nakagawa, Shuji Kaneko, Takashi Uehara, Masabumi Minami

Affiliation

¹ Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.

PMID: 17101179
DOI: 10.1016/j.bbr.2006.10.021

Abstract

Using a conditioned place paradigm, we examined the involvement of the bed nucleus of the stria terminalis (BST) in the negative affective component of visceral and somatic pain induced by intraperitoneal acetic acid and intraplantar formalin injections, respectively, in rats. Bilateral BST lesions suppressed both the acetic acid- and formalin-induced conditioned place aversion, suggesting the crucial role of the BST in the negative affective component of visceral and somatic pain.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetic Acid
Analysis of Variance
Animals
Avoidance Learning / physiology
Behavior, Animal
Conditioning, Psychological
Formaldehyde
Male
Neural Pathways / physiopathology*
Pain / chemically induced
Pain / physiopathology*
Pain Measurement / methods
Rats
Rats, Sprague-Dawley
Reaction Time / physiology
Septal Nuclei / injuries
Septal Nuclei / physiopathology*
Time Factors

Substances

Formaldehyde
Acetic Acid