Abstract
A novel series of malonamide derivatives was synthesized. These amides were shown to be potent and selective kappa opioid receptor agonists.
MeSH terms
-
Chemistry, Pharmaceutical / methods*
-
Cytochrome P-450 CYP2D6 / chemistry
-
Drug Design
-
Drug Evaluation, Preclinical
-
Humans
-
Inhibitory Concentration 50
-
Kinetics
-
Malonates / chemical synthesis*
-
Malonates / chemistry
-
Malonates / pharmacology*
-
Models, Chemical
-
Molecular Conformation
-
Receptors, Opioid, kappa / antagonists & inhibitors*
Substances
-
Malonates
-
Receptors, Opioid, kappa
-
Cytochrome P-450 CYP2D6
-
malonamide