Abstract
Twenty unsaturated sesquiterpene dialdehydes were tested for antimicrobial, algaecidal, cytotoxic, and mutagenic activity. In addition to the known antifungal activity, polygodial (1) also exhibited antibacterial and cytotoxic activity; epipolygodial (2) was slightly less active. The most active compounds were: isovelleral (7), isoisovelleral (8), velleral (20), and methylmarasmate (6). With the exception of velleral (20), they also exhibited mutagenic activity in the Salmonella/microsome assay. Derivatization to less polar compounds usually increased the antimicrobial and cytotoxic effects and reduced mutagenicity, while the introduction of hydroxyl groups had the reverse effect.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aldehydes
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Animals
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Anti-Bacterial Agents
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Anti-Infective Agents* / chemistry
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Anti-Infective Agents* / isolation & purification
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Antineoplastic Agents* / chemistry
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Antineoplastic Agents* / isolation & purification
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Bacteria / drug effects
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Basidiomycota / analysis*
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Chlorella / drug effects
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Drug Screening Assays, Antitumor
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Mice
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Mutagens / chemistry
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Mutagens / isolation & purification
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Plants / analysis*
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology*
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Structure-Activity Relationship
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Tumor Cells, Cultured
Substances
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Aldehydes
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Anti-Bacterial Agents
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Anti-Infective Agents
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Antineoplastic Agents
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Antineoplastic Agents, Phytogenic
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Mutagens
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Sesquiterpenes