Abstract
As part of our studies to discover P2X 7 receptor antagonists, the sponge Callyspongia sp. was investigated. A new tripyridine alkaloid niphatoxin C ( 1) was isolated and had P2X 7 receptor antagonism; however, cytotoxicity of THP-1 cells was the predominant biological effect at higher concentrations. Its structure was determined by 1- and 2-D NMR spectroscopy.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / blood
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology*
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Animals
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Antineoplastic Agents / blood
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology*
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Callyspongia / chemistry*
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Drug Screening Assays, Antitumor
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Humans
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Molecular Structure
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Monocytes / drug effects
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Purinergic P2 Receptor Antagonists*
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Pyridinium Compounds / blood
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Pyridinium Compounds / chemistry
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Pyridinium Compounds / isolation & purification*
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Pyridinium Compounds / pharmacology*
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Receptors, Purinergic P2X7
Substances
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Alkaloids
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Antineoplastic Agents
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P2RX7 protein, human
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Purinergic P2 Receptor Antagonists
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Pyridinium Compounds
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Receptors, Purinergic P2X7
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niphatoxin C